In Roche´s Pharmaceutical Research and Early Development organization (pRED), we make transformative medicines for patients in order to tackle some of the world’s toughest unmet healthcare needs. At pRED, we are united by our mission to transform science into medicines. Together, we create a culture defined by curiosity, responsibility and humility, where our talented people are empowered and inspired to bring forward extraordinary life-changing innovation at speed.
The pRED Oncology team is focused on discovering and developing step-change innovations in cancer immunotherapy and molecular targeted therapy for cancers where there are few treatment options, or where treatment choices simply don’t exist.
Our goal is to prioritize our best scientific discoveries, and then bring these innovations from the lab to the clinic as quickly, effectively and safely as possible, so patients can benefit from transformative medicines when they need them. The position is located in the department of Early Development Oncology.
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Job MissionThe Medical Director, Oncology - Early Development oversees and directs the activities of a scientific group in the research and/or development of an organization's products, projects and programs. Conducts and collaborates with others on basic research and development relevant to long-term objectives and concerns. Writes and reviews manuscripts for publication. Develops strategies to ensure effective achievement of scientific objectives. Monitors and evaluates completion of tasks and projects. May develop budgets for capital expenditures and labor. Typically collaborates with other top managers to establish company policies. Makes final decisions on administrative or operational matters. Selects, develops and evaluates employees to ensure the efficient operation of the function.
Your Impact
You are a key member in Early Development Teams driving projects from Clinical Candidate Selection (CCS) to the start of pivotal trials and Pivotal Go (Piv-Go).
You lead, plan, design, defend and ensure implementation of the Clinical Development Plan (CDP) with a molecule vision and strategy from early development to launch indication selection, including combination partners.
You steer the molecule integrated end-to-end development plan through the required clinical studies to achieve expedited Clinical Proof of Concept leading to seamless late-stage development and/or clinical program de-risking.
You drive the clinical program design, execution and scientific and medical data interpretation in line with GCP and highest medical and scientific standards, the most recent international treatment and health authority guidelines and cutting-edge disease endpoints, including novel and surrogate endpoints.
You create and foster global cross-functional collaboration together with the Project Team Leader to ensure timely regulatory, late stage, commercial and external expert input into our clinical programs to ensure the clinical strategy is translated into the development of a study protocol and related documents; be the main interface between Early Development Oncology and (1) Oncology Discovery, (2) Clinical Operations, (3) Business and (4) Late Stage, for project-related activities.
Additionally:
Key translational representative on discovery projects; shapes the hypotheses to be tested in clinical experiments
Work closely with the Biomarker Experimental Medicine Leader to develop biomarker strategies
Represent Roche at congresses and to local and international authorities
Maintain and expands a network of external principal investigators, clinical collaborators and advisors
Enable a patient- and site-centric Clinical Development Plan
Act as key clinical scientific contact / medical monitor / answers selected medical queries
Contributes to the review and interpretation of clinical data and the development of content needed for governance committee interactions seeking Go/No Go decisions
Participate in Due Diligences and non project related work streams representing the function / Department whenever applicable.
Publication of results of clinical programs.
Your Profile
You thrive in a dynamic, inclusive environment, which gives you full accountability for your own contributions and development. You have a keen interest in continuously building a personal network. You are resourceful and flexible in problem solving and in working in a collaborative and inclusive manner. You create an innovative and inclusive culture and have a sense for ensuring that everyone has the required information at all times.
You hold an MD with a board certification in Oncology/Hematology and minimum of 5 - 8 years of experience in clinical research (academia/industry), including experience in diverse working environments; physician scientist desirable
Preferably, you bring oncology drug development experience in the Pharmaceutical industry, including taking a compound to a Proof of Concept decision and general knowledge of all aspects and scientific methods used in Oncology Clinical Development, including both Early and Late stage
You are recognized as a thought leader in your field and are an advocate for change, encouraging adoption of new approaches, with agility and continuous improvement
You bring a strategic mindset and ecosystem thinking and strong analytical skills,strong communication and interpersonal skills; and the ability to influence others and drive consensus building
Our commitment
Roche commits to recognising talent and aptitude. We prioritize encouraging and supporting our employees in their personal journeys by providing a safe, creative space to help them reflect, make decisions and grow in their career. We are confident that we find the most innovative solutions by gaining different perspectives, asking and answering hard questions, and challenging the status quo.
Roche embraces diversity and equal opportunity in a serious yet enthusiastic way; we are devoted to building a team that represents a range of backgrounds, perspectives, and skills. The more inclusive we are, the better our work will be.
At Roche, more than 100,000 people across 100 countries are pushing back the frontiers of healthcare. Working together, we’ve become one of the world’s leading research-focused healthcare groups. Our success is built on innovation, curiosity and diversity.
Basel is the headquarters of the Roche Group and one of its most important centres of pharmaceutical research. Over 10,700 employees from over 100 countries come together at our Basel/Kaiseraugst site, which is one of Roche`s largest sites. Read more.
Besides extensive development and training opportunities, we offer flexible working options, 18 weeks of maternity leave and 10 weeks of gender independent partnership leave. Our employees also benefit from multiple services on site such as child-care facilities, medical services, restaurants and cafeterias, as well as various employee events.
We believe in the power of diversity and inclusion, and strive to identify and create opportunities that enable all people to bring their unique selves to Roche.
Roche is an Equal Opportunity Employer.
